Oxygenated derivatives of cholesterol (oxysterols) are widely distributed in nature, being found in the blood and tissues of animals and man as well as in foodstuff. They exhibit many biological activities which are of potential physiological, pathological or pharmacological importance. Many oxysterols have been found to be potent inhibitors of cholesterol biosynthesis and one or more oxysterols may play a role as the physiologic feedback regulator of cholesterol synthesis. Oxysterols also inhibit cell replication and have cytotoxic properties effects which suggest (...) that these sterols may participate in the regulation of cell proliferation and may be potentially useful as therapeutic agents for cancer. Furthermore, there is considerable evidence that oxysterols may be involved in the pathogenesis of atherosclerosis. Although the mechanism of action of oxysterols in all these instances is not well understood, the existence of cytosolic and microsomal proteins which bind oxysterols with high affinity and specificity suggests that this group of compounds may represent a family of intracellular regulatory molecules. (shrink)

The study of intellectual humility is still in its early stages and issues of definition and measurement are only now being explored. To inform and guide the process of defining and measuring this important intellectual virtue, we conducted a series of studies into the implicit theory – or ‘folk’ understanding – of an intellectually humble person, a wise person, and an intellectually arrogant person. In Study 1, 350 adults used a free-listing procedure to generate a list of descriptors, one for (...) each person-concept. In Study 2, 335 adults rated the previously generated descriptors by how characteristic each was of the target person-concept. In Study 3, 344 adults sorted the descriptors by similarity for each person-concept. By comparing and contrasting the three person-concepts, a complex portrait of an intellectually humble person emerges with particular epistemic, self-oriented, and other-oriented dimensions. (shrink)

In this paper, we explore the literature on cognitive heuristics and biases in light of virtue epistemology, specifically highlighting the two major positions—agent-reliabilism and agent-responsibilism —as they apply to dual systems theories of cognition and the role of motivation in biases. We investigate under which conditions heuristics and biases might be characterized as vicious and conclude that a certain kind of intellectual arrogance can be attributed to an inappropriate reliance on Type 1, or the improper function of Type 2, cognitive (...) processes. By the same token, the proper intervention of Type 2 processes results in the virtuous functioning of our cognitive systems. Moreover, the role of motivation in attenuating cognitive biases and the cultivation of certain epistemic habits points to the tenets of agent-responsibilism.. (shrink)

The many gods of modernity -- The dynamics of relativization -- Relativism -- Fundamentalism -- Certainty and doubt -- The limits of doubt -- The politics of moderation.

In this follow up to The Eudemian Ethics of Aristotle, Peter L. P. Simpson centers his attention on the basics of Aristotelian moral doctrine as found in the Great Ethics: the definition of happiness, the nature and kind of the virtues, pleasure, and friendship. This work's authenticity is disputed, but Simpson argues that all the evidence favors it. Unlike the Nicomachean and Eudemian Ethics, Aristotle wrote the Great Ethics for a popular audience. It gives us insight less into Aristotle (...) the theoretician than into Aristotle the pedagogue. For this reason, the Great Ethics has distinct advantages as an introduction to Aristotelian ethical thinking: it is simpler and clearer in its argumentation, matters such as the intellectual virtues are made suitably secondary to the practical focus, the moral virtues come through with a pleasing directness, and the work's syllogistic formalism gives it a transparency and accessibility that the other Ethics typically lack. Arius' Epitome, which relies heavily on this work, helps confirm its value and authenticity. Because the Great Ethics is generally neglected by scholars, less has been done to clear up its obscurities or to expose its structure. But to ignore it is to lose another and more instructive way of approaching and appreciating Aristotle's teaching. The translation is prefaced by an analytic outline of the whole, and the several sections of it are prefaced by brief summaries. The commentary supplies fuller descriptions and analyses, sorting out puzzles, removing misunderstandings, and resolving doubts of meaning and intention. This book is a fresh rendition of the work of the preeminent philosopher of all time. (shrink)

Among the works on ethics in the Aristotelian corpus, there is no serious dispute among scholars that the "Eudemian Ethics "is authentic. The "Eudemian Ethics "is" "increasingly read and used by scholars as a useful support and confirmation and sometimes contrast to the "Nicomachean Ethics." Yet, it remains a largely neglected work in the study of Aristotle's ethics, both among scholars and moral philosophers. Peter L. P. Simpson provides an analytical outline of the entire work together with summaries of (...) each individual section, making the overall structure and detailed argument clear. His translation and explanatory notes include the common books that the "Eudemian" "Ethics" shares with the "Nicomachean." This translation contains renderings of words and phrases, and proposals for emending the text that differ from what other translators and scholars have adopted. This translation is literal, without expansion or paraphrase, and yet also readable. A readable but literal translation is necessary because in the "Eudemian Ethics," more than usual in Aristotle's writings, the logic of the argumentation can turn on the peculiar wording or order. Simpson explains the argumentation where necessary in notes and separate explanatory comments. This book is a fresh, twenty-first-century rendition of the work of one of the most eminent philosophers of all time. (shrink)

Aristotle's Ethica Eudemia and Ethica Nicomachea, as is well known and much discussed, contain three books in common. Less well known, at least until Dieter Harlfinger alerted scholars to the fact in 1971, is that some of the manuscripts of Eth. Eud. do, contrary to the then prevailing consensus, contain the text of these common books. Even less well known is that Harlfinger's discovery was anticipated some 50 years before by Walter Ashburner, who had uncovered this fact about Eth. Eud. (...) MSS in the Laurentian library of Florence. Ashburner's anticipation of Harlfinger, however, is not the real value of his article. Its value rather is that it contains collations of readings for the common books, and thereby gives us an excellent resource for examining the text of the common books as this text is contained in exclusively Eth. Eud. MSS. The Eth. Eud. tradition of the common books has hitherto received little attention. Modern editions of Eth. Eud. do not include these books, and editions of Eth. Nic. have other MSS for the purpose. Ashburner's collations are the more valuable because they are taken from the one MS that, in Harlfinger's learned stemma, appears as the archetype for all the rest. (shrink)

Two intellectual vices seem to always tempt us: arrogance and diffidence. Regarding the former, the world is permeated by dogmatism and table-thumping close-mindedness. From politics, to religion, to simple matters of taste, zealots and ideologues all too often define our disagreements, often making debate and dialogue completely intractable. But to the other extreme, given a world with so much pluralism and heated disagreement, intellectual apathy and a prevailing agnosticism can be simply all too alluring. So the need for intellectual humility, (...) open-mindedness, and a careful, humble commitment to the truth are apparent. In this book, Dr Church and Dr Samuelson explicate a robust and vibrant account of the philosophy and science of this most valuable virtue, and they highlight how it can be best applied and personally developed. (shrink)

It has been maintained that we are quite able to express (1*)–(4*) without the introduction of a dyadic deontic operator, provided only that we supply our standard deontic logic with a stronger conditional than material implication. The lesson learned from Chisholm's paradox has been the eminently convincing, indeed obvious, one: that what we ought to do is not determined by what is the case in some perfect world, but by what is the case in the best world we can ‘get (...) to’ from this world. What we ought to do depends upon how we are circumstanced. (shrink)

ABSTRACT:In this paper we examine how ethical values contribute to national economic prosperity. We extend the concept of an ethical wealth of nations first introduced by Donaldson in which he proposed four categories of ethical values—fairer distribution of goods, better government, ingrained social cooperation, and inculcation of economic duties—that can drive economic performance, but only if citizens ascribe “intrinsic value” to them independent of their economic interests. Our analysis draws on institutional economics and sociology research to show that if ethical (...) values are to drive economic performance, they must also be supported by the institutional fabric of the nation. We embed an expanded set of ethical values in a set of democratic, free market and civil society institutions spanning three sectors of society—political, economic and cultural respectively. We conclude by discussing the implications of our institutional framework for moral education. (shrink)

No descriptive material is available for this title.

This paper began with the simple object of finding an account that allowed us to compare incompatible false theories. This we achieved with ρ. But that relation is language — or interest — dependent. ρ' is free from this limitation; though thus liberated it is perhaps rather unconcerned about what is true, and further fails to deliver certain intuitive comparisons. Whether ρ is to be preferred to ρ' or vice versa, seems to me a largely fruitless question: In fact it (...) might be that as we seek to free the idea of verisimilitude from any dependence on language, interests or problems, so we gradually collapse it to nothing more than logical power. (shrink)

Aus dem Zusammentreffen der Philosophischen Anthropologie mit der interdisziplinären Rhetorikforschung sind heute zwei neue komplementäre Tochterdisziplinen entstanden. Die eine ist die fundamentalrhetorische Anthropologie, welche den Menschen generell als homo rhetoricus definiert. Die andere klärt als rhetorische Metakritik die Philosophie selbst über ihre eigene, immanente Rhetorizität auf. Der vorliegende Band präsentiert exemplarische Beiträge zu diesem neuen rhetorischen Denken in zwei Teilen. Der erste enthält unter dem Titel „Zur Philosophie der Rhetorik“ die Arbeiten zur fundamentalrhetorischen Anthropologie. Ausgehend von grundlegenden Thesen zur Homo-rhetoricus-Anthropologie (...) behandeln sie Themen wie z.B. Pithanologie, Pathelogie, Polypersonalität, Anthropotechnik, Autoinvenienz oder die Rekonstruktion des Subjektbegriffes durch interne Rhetorik. Der zweite Teil „Zur Rhetorik der Philosophie“ umfasst die Beiträge, welche der rhetorischen Metakritik der Philosophie und ihrer Geschichte zuzurechnen sind. Hier finden sich u.a. Abhandlungen zur Topographie der klassischen Metaphysik und ihren sophistischen und pararhetorischen Gegenspielern sowie metakritische Detailstudien zu Pseudo-Longin, Kant, Hegel, Fichte und Heidegger. (shrink)